Adding resveratrol to the diet of yeast, fruit flies, worms, and a species of fish increased their life spans up to 70%, 29%, 24%, & 50% respectively.
Resveratrol made fat related deaths drop 31% in obese mice.
The resveratrol fed obese mice also performed much better
in movement and agility tests than obese mice not
fed resveratrol.
Mice fed resveratrol had 100% more endurance than mice
not fed resveratrol (i.e. they were able to run twice as far
on a treadmill).
Resveratrol inhibits blood platelet aggregation that can
lead to dangerous clots that can cause heart attacks and
strokes.
Resveratrol is a powerful antioxidant that can help prevent
cell damage caused by free radicals (free radicals are
unstable atoms caused in part by pollution, sunlight, and our bodies natural burning of fat that can lead to cancer, aging,
and brain degeneration)
Resveratrol has been proven to fight cancer in vitro at all
three stages; (1) initiation, (2) promotion, (3) progression.
Researchers found adding resveratrol, an organic compound found in grapes and particularly in red wine, to the daily diet of short-lived fish prolonged their lifespan and delayed the onset of age-related memory and other problems. Resveratrol is one of a group of antioxidant compounds called polyphenols found in red wine that has been reported to have anti-inflammatory as well as anticancer properties and is currently being studied for a variety of pharmaceutical uses.
Some researchers believe that resveratrol might be the key ingredient in red wine that helps prevent damage to blood vessels, reduces "bad" cholesterol and prevents blood clots. Research in mice given resveratrol has indicated that the antioxidant might also help protect them from obesity and diabetes, both of which are strong risk factors for heart disease. However, those findings were reported only in mice, not in people. In addition, to achieve the dose of resveratrol used in the mice studies, a person would have to consume 100 to 1,000 bottles of red wine a day.
Resveratrol extends the lifespan of diverse species. Here we show that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK), increased mitochondrial number, and improved motor function. These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing.
If you haven't heard of resveratrol, you're probably too young to have had the experience of gazing into the bathroom mirror in the morning and thinking, woah, I need a new look!" Resveratrol is the ingredient in red wine that made headlines in November when scientists demonstrated that it kept overfed mice from gaining weight, turned them into the equivalent of Olympic marathoners, and seemed to slow down their aging process. Few medical discoveries have generated so much instant buzz - even Jay Leno riffed about it in his opening monologue.
Resveratrol is a chemical found in the skin of grapes and in red wine that has long been conjectured to be a partial explanation for the French paradox, the puzzling fact that people in France enjoy a high-fat diet yet suffer less heart disease than Americans. More recently, scientists have been exploring whether resveratrol could extend lifespan as well.
The hope is that resveratrol or a compound based on it could mimic the effects of a severely restricted diet, which has been shown to extend the life of mice. A low level of caloric intake appears to activate a class of proteins known as sirtuins that regulate metabolism; researchers have shown that other subtances can trigger sirtuins, and resveratrol appears to be particularly potent at that task.
Scientists caution that results involving animals often do not translate into drugs that work in humans. And the experiments conducted so far have been based on a level of resveratrol consumption that would be impractical, to say the least one involved the equivalent of drinking 100 bottles of red wine a day, while a later study brought that down to about 35. Researchers are hoping to find a way to concentrate the effect into a manageable dose.
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While it has been know for thousands of years that wine is a
healthful drink (thus the old Roman saying 'In Vino Sanitas'- In wine
there is health), the scientific community started taking wine's health
benefits seriously after 60 Minutes reported the famous 'French
Parodox' study in which people in France were less likely to die
of heart attacks than Americans despite s imilar high fat diets.
The study concluded
that the relatively large amounts of
red wine consumed by the
French protected their hearts.
Collagen is the component in our body that basically helps
hold us together. It is present in our skin, bones cartilage and
otherconnective tissues and is crucial to maintaining a youthful
body and appearance. The reason that many of us feel we are
rapidly falling down hill when it comes to the aging process is
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we begin to lose collagen at the rate of 1.5% a year which means
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What Makes the Pomegranate So Special?
It's true that other fruits contain many different types of
antioxidants, but the pomegranate is the only one to contain the
three major antioxidants: tannins, anthocyanins and ellagic acid.
Antioxidants arewhat help to boost the body's immune system.
These high concentrations of antioxidants help to protect the body
from the damaging effects of pollution, cancer diabetes and many
other debilitating diseases. In some cases, increasing the body's
level of antioxidants is rumored to slow the aging process.
With such a high concentration of antioxidants, it's no wonder that r
esearchers believe that the major pomegranate benefits would help
reduce heart disease, clogged arteries and hypertension.
The High Antioxidant count helps fight cell deterioration.
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Resveratrol prevented age-related and obesity-related cardiovascular functional decline in the mice as determined by several parameters. Total cholesterol was significantly reduced in 22-month-old non-obese mice after 10 months of resveratrol treatment.
-National Institute of Health
Resveratrol produced large reductions in brain plaque in the hypothalamus, striatum, and medial cortex sections of the brain. In humans it is theorized that oral doses of resveratrol may reduce beta amyloid plaque associated with aging changes in the brain. Researchers theorize that one mechanism for plaque eradication is the ability of resveratrol to chelate (remove) copper.- Weill Cornel Medical Center